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研究棕榈酰基-KVK-L-抗坏血酸对皮肤皱纹和色素沉着的影响

更新日期:2018年01月23日

摘要

皱纹形成和异常色素沉着是与皮肤老化有关的主要临床改变。本研究旨在研究棕榈酰基-KVK-L-抗坏血酸对皮肤老化的影响,通过测定真皮成纤维细胞的表达并分别抑制B16F1细胞中的黑素生成,进而来评价棕榈酰基-KVK-L-抗坏血酸的抗皱和脱色素作用。在临床试验中,棕榈酰基-KVK-L-抗坏血酸乳膏的抗衰老作用是对照安慰剂乳膏的作用来进行评估的。

我们的研究结果证实使用棕榈酰基-KVK-L-抗坏血酸(0.1-4μg/ mL)处理的真皮成纤维细胞中的I型胶原的表达以剂量依赖性方式增加。在B16F1细胞中,与α-促黑素细胞激素治疗相比,用20μg/ mL棕榈酰基-KVKL-抗坏血酸来治疗使黑素含量降低约了20%。

在临床试验中,使用了棕榈酰基-KVK-L-抗坏血酸乳膏的12周和8周内,我们观察到皮肤的粗糙度和亮度均得到改善。我们的数据表明棕榈酰-KVK-L-抗坏血酸是一种有效的抗衰老剂,可减少皱纹和异常的皮肤色素沉着。



(英文原文)Effects of palmitoyl-KVK-L-ascorbic acid on skin wrinkles and pigmentation


Abstract

  Wrinkle formation and abnormal pigmentation are major clinical alterations associated with skin aging. As the aim of our study was to investigate the effects of palmitoyl- KVK-L-ascorbic acid on skin aging, the anti-wrinkle and depigmentation effects of palmitoyl-KVK-L-ascorbic acid were evaluated by measuring collagen expression in dermal fibroblast cells and inhibition of melanogenesis in B16F1 cells, respectively. The anti-aging effect of palmitoyl-KVK-L-ascorbic acid cream was also evaluated against a placebo cream in a clinical trial. Our results confirmed that the expression of type Ι collagen in dermal fibroblast cells treated with palmitoyl-KVK-L-ascorbic acid (0.1–4 μg/mL) increased in a dose-dependent manner. In B16F1 cells, treatment with 20 μg/mL palmitoyl-KVKL-ascorbic acid reduced the melanin content by approximately 20% compared to alpha-melanocyte stimulating hormone treatment. In the clinical trial, application of palmitoyl-KVK-L-ascorbic acid cream led to an improvement in skin roughness and lightness in 12 and 8 weeks, respectively. Our data show that palmitoyl-KVK-L-ascorbic acid is an effective anti-aging agent that reduces wrinkles and abnormal skin pigmentation.


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