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《IOP Conf. Ser.:Mater. Sci. Eng.》关于抗痤疮膏的制备研究

更新日期:2017年12月22日

白羽叶乙醇提取物抗痤疮膏的研制

 

  摘要 痤疮是毛囊皮脂腺的一种慢性炎症性皮肤病,皮肤产油腺被细菌堵塞和污染。痤疮丙酸杆菌是引发痤疮的细菌之一。而痤疮治疗正是通过使用抗菌剂减少细菌数量来实现的。我们发现了一种具有抗菌活性的植物——白羽叶。白羽叶的乙醇提取物含有抗菌的次级代谢产物,即生物碱和皂甙。本研究的目的是将白羽叶提取物配制到水浸膏基质中。通过评价软膏的稳定性,包括感官,粘附力测试,分散力测试,pH测定和抗菌活性测试来确定软膏的特性。结果表明,白羽叶乙醇提取物软膏具有以下的特点,均匀半固体形式,白色,有独特的软膏气味,pH值为4.57 - 6.10,分散力为5.10 - 6.06 cm,粘合性为1.67-3秒,并且在浓度为5ppm时有24.00mm的抑制区,表现出最佳的抗菌活性。




(原文)Synthesis of Anti-Acne Ointment of Ethanol Extract of White Plumeria Leaves (Plumeria Alba L.)

 

  Abstract Acne is a chronic inflammatory skin disease pilosebaceous follicle, where the oilproducing glands are clogged and contaminated by bacteria. Propionibacterium acne is one of the bacteria that contributes to the pathogenesis of acne. Acne treatment was done by reducing the population of bacteria using an antibacterial. One of the plants that have antibacterial activity is white plumeria. The ethanol extract of white plumeria leaves contains antibacterial secondary metabolites, which are alkaloids and saponins. The aim of this study is to formulate white plumeria leaves extract into the water leached ointment base. Characteristics of the ointment were determined by evaluating the stability of the ointment including organoleptic,adhesion test, dispersive power test, determination of pH, and the antibacterial activity test.The results showed that the ointment of ethanol extract of white plumeria leaves has some characteristics, semisolid form, white, has distinctive smell of ointment, homogeneous but not protective, has a pH of 4.57 - 6.10, dispersive power of 5.10 - 6.06 cm, the adhesiveness of 1.67 - 3 seconds, and optimum antibacterial activity at concentrations of 5 ppm providing inhibition zone of 24.00 mm.



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