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《Int J Womens Dermatol》关于寻常性痤疮的研究

更新日期:2017年12月01日

《痤疮问题》

摘要

  寻常性痤疮是小学和中学时期三种世界上最常见的皮肤问题之一。它的诊断和治疗可追溯到古希腊和埃及时代。本文探讨了痤疮的历史,讨论了以往的病因和治疗理论,并重点研究了类维生素A的发现及其对女性健康的影响。

The age-old problem of acne(原文) 

  Acne vulgaris is one of the top three most commonly encountered dermatological problems worldwide in both primary and secondary care. Acne diagnosis and treatment date back to ancient Greek and Egyptian times. This article explores acne through the ages and discusses past theories on etiology and treatment with particular focus on the discovery of retinoids and their impact on women’s health. 



《痤疮发病机制的新见解:探索与痤疮相关的微生物种群的作用》

摘要

  寻常性痤疮是一种常见的皮肤疾病,它会增加患者的自杀意念发生率(约7.1%)。这就引出了一个问题,即对人类来说痤疮是否是一种威胁生命的疾病。这种多因素疾病的主要诱因是皮肤上常见微生物的波动,而每种微生物对人体的保护都有自己的目的和方法。对痤疮来说,微生物种群必须绕过宿主皮肤的防御屏障,并能抵抗皮肤屏障才能生存。这些问题已经通过研究其致病生命周期以及在其单个环状染色体中的致病岛内编码的相关毒性因子得以解决。本文通过强调痤疮的致病机制以及与痤疮形成相关的毒性因子的基因,研究了痤疮病变和促进痤疮的不同微生物种群。我们还建立了模型系统,如动物模型和细胞培养模型来研究微生物的致病方式。

New insights into acne pathogenesis: Exploring the role of acne-associated microbial populations (原文)

  Acne vulgaris, a prevalent disorder of the skin, is found to increase the incidence of suicidal ideation in acne patients (~7.1%). This creates a dilemma in the mind whether acne is a life threatening disease among humans. The main inducer for this multifactorial disease is microbial fluctuation of common resident microbes on the skin with each microbe possessing their own purpose and style in protecting the human body. For acne progression, the microbial population has to get around the defense barriers of the host skin and be able to also resist them in order to survive. These matters have been resolved by their pathogenic lifecycle and associated virulence factors coded within their pathogenic islands in the single circular chromosome. This review addresses the different microbial populations residing in acne lesions and promoting acne by emphasizing their pathogenic mechanisms and the genes associated with virulence factors involved in the development of acne. Model systems such as animal models and cell culture models in studying the pathogenic lifestyle of the microbes are also addressed.

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