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《INT J COSMETIC SCI》关于敏感性肌肤的综述

更新日期:2017年11月02日


摘要

敏感性皮肤是主观者对于环境反应强烈的一种状态。实验表明当受试者的皮肤接触到化妆品、肥皂和日光时,会产生夸张的反应,而且他们的皮肤在干燥寒冷的气候条件下会发生恶化。虽然通常没有发现刺激的迹象,但瘙痒、烧灼感、刺痛感和紧张感持续存在。通常不认为是刺激物与这种异常反应有关,敏感皮肤和主观刺激广泛存在,但还远未定义完全和理解。敏感皮肤与体质异常或其他触发因素有关,如职业性皮肤病与慢性接触刺激之间的相关性假设已被提出。最近的研究结果表明,敏感性皮肤更可能是由于不同的机制。超级反应堆可能有较薄的角质层使角质细胞区域减少造成了水溶性化学物质经皮渗透性更高。本文描述了在辣椒素受体变化神经元的改变。像皮肤屏障功能之类的监测参数,倾向于刺激角质细胞的大小,通过感官传输也可以找出有用的皮肤敏感的区域差异。





(原文)

Sensitive skin: an overview


Synopsis

Sensitive skin is a condition of subjective cutaneous hyper-reactivity to environmental factors. Subjects experiencing this condition report exaggerated reactions when their skin is in contact with cosmetics, soaps and sun screens, and they often report worsening after expo-sure to dry and cold climate. Although no sign of irritation is com-monly detected, itching, burning, stinging and a tight sensation are constantly present. Generally substances that are not commonly considered irritants are involved in this abnormal response.Sensitive skin and subjective irritation are widespread but still far from being completely defined and understood. A correlation between sensitive skin and constitutional anomalies and/or other triggering factors such as occupational skin diseases or chronic exposure to irritants has been hypothesized. Recent findings suggest that higher sensitiv-ity can be due to different mechanisms. Hyper-reactors may have a thinner stratum corneum with a reduced corneocyte area causing a higher transcutaneous penetration of water-soluble chemicals. Alter-ations in vanilloid receptors and changes in neuronal transmission have been described. Monitoring skin parameters such as barrier function, proclivity to irritation, corneocyte size and sensorial trans-mission can also be useful to identify regional differences in skin sen-sitivity.

 



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