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健康皮肤的微生物菌群研究

更新日期:2017年09月13日

我们的皮肤与生俱来就是一个复杂的屏障系统,微生物菌群和宿主组织间通过先天免疫系统和适应性免疫系统提供的复杂信号而共生。由于持续受到因暴露于内外因素而产生的影响,导致了微生物菌群和宿主组织间的失衡,从而产生了炎症性皮肤如感染、过敏或是自身免疫性疾病。不像肠道菌群和粪便菌群一样被研究了很多年,皮肤微生物菌群的研究是最近才刚开始的。微生物学和皮肤医学的研究者们通过现代的方法如焦磷酸测序技术分析细菌的16S rRNA基因,标记皮肤上不同的微生物菌群,由此评估细菌的多样性和它们的相关性,使人们能更好地了解微生物多样性对皮肤健康和皮肤状况的重要性。这篇文章的目的在于提供一篇有关皮肤的微生物组学、微生物群系及它们在皮肤医学中的重要性方面的综述。



(原文)


Microbiome in healthy skin, update for dermatologists

Abstract

The skin is a complex barrier organ made of a symbiotic relationship between microbial communities and host tissue via complex signals provided by the innate and the adaptive immune systems. It is constantly exposed to various endogenous and exogenous factors which impact this balanced system potentially leading to inflammatory skin conditions comprising infections, allergies or autoimmune diseases. Unlike the gut and stool microbiome which has been studied and described for many years, investigations on the skin or scalp microbiome only started recently. Researchers in microbiology and dermatology started using modern methods such as pyrosequencing assays of bacterial 16S rRNA genes to identify and characterize the different microorganisms present on the skin, to evaluate the bacterial diversity and their relative abundance and to understand how microbial diversity may contribute to skin health and dermatological conditions. This article aims to provide an overview on the knowledge about the skin microbiota, the microbiome and their importance in dermatology. 



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